For those interested in a more scientific and thorough study of different cancers and treatments in dogs, the USDA publishes abstracts, the articles from which can be accessed on line. These articles are from the journal: Veterinary and comparative oncology, publication year 2019.
Author: Meier, Valeria; Besserer, Jürgen; Roos, Malgorzata; Rohrer Bley, Carla
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 21-31
ISSN: 1476-5810
Subject: adenocarcinoma; anal glands; bladder; computed tomography; confidence interval; data collection; dogs; hemorrhage; kidneys; patients; radiotherapy; risk; risk estimate; small intestine; spinal cord; stomach; toxicity
Abstract: … Previous trials showed the importance of administering radiation therapy (RT) with small doses per fraction in canine pelvic tumours to maintain acceptable toxicity levels. With increased accuracy/precision of RT, namely intensity‐modulated RT (IMRT), this approach might be challenged. Theoretical toxicity calculations for a new definitive‐intent moderately hypofractionated RT protocol for canine …
DOI: 10.1111/vco.12441
Author: Withers, Sita S.; Skorupski, Katherine A.; York, Daniel; Choi, Jin W.; Woolard, Kevin D.; Laufer‐Amorim, Renee; Sparger, Ellen E.; Rodriguez, Carlos O.; McSorley, Stephen J.; Monjazeb, Arta M.; Murphy, William J.; Canter, Robert J.; Rebhun, Robert B.
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 49-60
ISSN: 1476-5810
Subject: adjuvants; amputation; biomarkers; dogs; humans; humerus; immunohistochemistry; immunotherapy; macrophages; osteosarcoma
Abstract: … Immunotherapeutic strategies have shown promise for the treatment of canine osteosarcoma (cOSA). Very little is known about the immune microenvironment within cOSA, however, limiting our ability to identify potential immune targets and biomarkers of therapeutic response. We therefore prospectively assessed the disease‐free interval (DFI) and overall survival time (ST) of 30 dogs with cOSA treated …
DOI: 10.1111/vco.12444
Author: Hartley, Genevieve; Elmslie, Robyn; Murphy, Brent; Hopkins, Leone; Guth, Amanda; Dow, Steven
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 69-79
ISSN: 1476-5810
Subject: B-lymphocytes; T-cell lymphoma; aldehyde dehydrogenase; cytotoxicity; dogs; drug resistance; drug therapy; enzyme activity; flow cytometry; in vitro studies; lymph nodes; metastasis; neoplasm cells; phenotype; relapse; stem cells
Abstract: … Cancer relapse following chemotherapy has been attributed in part to the presence of cancer stem cells (CSC), which drive tumour growth and metastasis and are highly resistant to the effects of cytotoxic chemotherapy. As a result, treatment with cytotoxic chemotherapy selects for drug‐resistant CSC populations that eventually drive tumour recurrence. Little is known currently regarding the role of …
DOI: 10.1111/vco.12447
Author: Woodruff, Matthew J.; Heading, Kathryn L.; Bennett, Peter
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 42-48
ISSN: 1476-5810
Subject: adenocarcinoma; databases; dogs; drug therapy; radiotherapy; retrospective studies; sarcoma; squamous cell carcinoma
Abstract: … Few veterinary studies have evaluated the response to chemotherapy treatment of canine intranasal tumours, while many have focused on the efficacy of radiation therapy. Given the higher costs and limited access to radiation therapy, alternative treatment options are needed. The study describes a cohort of dogs with histologically confirmed intranasal tumours treated with chemotherapy as a sole the …
DOI: 10.1111/vco.12443
Author: Willmann, Michael; Hadzijusufovic, Emir; Hermine, Olivier; Dacasto, Mauro; Marconato, Laura; Bauer, Karin; Peter, Barbara; Gamperl, Susanne; Eisenwort, Gregor; Jensen‐Jarolim, Erika; Müller, Mathias; Arock, Michel; Vail, David M.; Valent, Peter
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 1-10
ISSN: 1476-5810
Subject: dogs; enzyme inhibitors; evolution; humans; mast cells; models; mutation; prognosis; skin neoplasms
Abstract: … In humans, advanced mast cell (MC) neoplasms are rare malignancies with a poor prognosis. Only a few preclinical models are available, and current treatment options are limited. In dogs, MC neoplasms are the most frequent malignant skin tumours. Unlike low‐grade MC neoplasms, high‐grade MC disorders usually have a poor prognosis with short survival. In both species, neoplastic MCs display activati …
DOI: 10.1111/vco.12440
Author: Kim, Sangho; Hosoya, Kenji; Kobayashi, Ayumi; Okumura, Masahiro
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 61-68
ISSN: 1476-5810
Subject: adverse effects; blood; blood chemistry; blood volume; dogs; granulocyte colony-stimulating factor; hematopoietic stem cells; therapeutics
Abstract: … Peripheral blood stem cell (PBSC) transplantation following consolidation therapy is a feasible treatment option for canine haematological malignancies. In veterinary medicine, haematopoietic stem cells are generally mobilized into peripheral circulation using a granulocyte colony‐stimulating factor (G‐CSF). This pilot study aimed to evaluate the haematopoietic stem cell mobilization effect of thr …
DOI: 10.1111/vco.12446
Author: Shimizu, N.; Hamaide, A.; Dourcy, M.; Noël, S.; Clercx, C.; Teske, E.
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 11-20
ISSN: 1476-5810
Subject: CCR2 receptor; adhesion; biomarkers; blood serum; carcinogenesis; carcinoma; chemokine CCL2; chemotaxis; dogs; endothelium; enzyme-linked immunosorbent assay; growth factors; humans; ligands; metastasis; monocytes; urinary tract diseases; urine
Abstract: … Chemokine (C‐C motif) ligand 2 (CCL2) is a chemotactic cytokine recruiting monocytes, releasing growth factors and promoting adhesion in vascular endothelium. Elevated serum and urinary CCL2 levels and expression of its receptor (CCR2) have been associated with tumorigenesis in human urinary malignancies. CCL2 implication has not been investigated in canine urothelial carcinoma. The aim of this st …
DOI: 10.1111/vco.12436
Author: Ryu, Min‐Ok; Kim, Byung‐Gak; Choi, Ul‐Soo; Baek, Kwan‐Hyuck; Song, Young‐Ki; Li, Qiang; Seo, Kyoung‐Won; Ryeom, Sandra; Youn, Hwa‐Young; Bhang, Dong‐Ha
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 99-106
ISSN: 1476-5810
Subject: C-reactive protein; autoantibodies; biomarkers; blood serum; cAMP-dependent protein kinase; cyclic AMP; dogs; enzyme-linked immunosorbent assay; neoplasm cells; neoplasms
Abstract: … Protein kinase A, a cyclic adenosine monophosphate (AMP)‐dependent enzyme, normally exists within mammalian cells; however, in cancer cells, it can leak out and be found in the serum. Extracellular cyclic AMP‐dependent protein kinase A (ECPKA) has been determined to increase in the serum of cancer‐bearing dogs. However, there have been no reports in the veterinary literature on serum ECPKA autoant …
DOI: 10.1111/vco.12450
Author: Selmic, Laura E.; Samuelson, Jonathan; Reagan, Jennifer K.; Mesa, Kelly J.; Driskell, Elizabeth; Li, Joanne; Marjanovic, Marina; Boppart, Stephen A.
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 80-88
ISSN: 1476-5810
Subject: adipose tissue; breast neoplasms; clinical trials; dogs; histology; histopathology; humans; image analysis; muscles; resection; sarcoma; skeletal muscle; texture; tomography; veterinary medicine
Abstract: … Optical coherence tomography (OCT) is a rapid non‐invasive imaging technique that has shown high sensitivity for intra‐operative surgical margin assessment in human breast cancer clinical trials. This promising technology has not been evaluated in veterinary medicine. The objective of this study was to correlate normal and abnormal histological features with OCT images for surgical margins from ex …
DOI: 10.1111/vco.12448
Author: Reckelhoff, Caroline R.; Lejeune, Amandine; Thompson, Patrick M.; Shiomitsu, Keijiro
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 32-41
ISSN: 1476-5810
Subject: apoptosis; caspases; cell cycle checkpoints; cell lines; dogs; drug therapy; drugs; fibroblast growth factor 2; flow cytometry; hemangiosarcoma; inhibitory concentration 50; nanoparticles; paclitaxel; reverse transcriptase polymerase chain reaction; vascular endothelial growth factors; water solubility
Abstract: … Paccal Vet (Osamia Pharmaceuticals) is a water‐soluble nanoparticle micellar formulation of the drug paclitaxel that is well tolerated in dogs. This study evaluated the in vitro effect of Paccal Vet on two canine hemangiosarcoma (HSA) cell lines and their expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Paccal Vet caused HSA cell death in a dose‐ a …
DOI: 10.1111/vco.12442
Author: Unger, Lucia; Gerber, Vinzenz; Pacholewska, Alicja; Leeb, Tosso; Jagannathan, Vidhya
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 107-117
ISSN: 1476-5810
Subject: algorithms; biomarkers; blood serum; gene expression regulation; hemolysis; high-throughput nucleotide sequencing; horses; humans; leukocyte count; microRNA; prediction; sarcoid
Abstract: … Serum and whole blood microRNA (miRNA) fingerprints have been proposed as a new class of non‐invasive human cancer biomarkers. In this study, we compared equine sarcoid (ES) disease‐specific serum and whole blood miRNA fingerprints and correlated them to miRNA expression in sarcoid tissue. After high throughput sequencing, miRNA differential expression analysis between six ES‐affected and five con …
DOI: 10.1111/vco.12451
Author: Favril, Sophie; Stock, Emmelie; Hernot, Sophie; Hesta, Myriam; Polis, Ingeborgh; Vanderperren, Katrien; de Rooster, Hilde
Source: Veterinary and comparative oncology 2019 v.17 no.1 pp. 89-98
ISSN: 1476-5810
Subject: animal models; dogs; fluorescence; fluorescent dyes; image analysis; lymph nodes; microbubbles; near-infrared spectroscopy; neoplasms; patients
Abstract: … Sentinel lymph node (SLN) mapping is a valuable and crucial diagnostic procedure in staging malignancies. We compared two non‐invasive techniques, near‐infrared (NIR) fluorescence imaging and contrast‐enhanced ultrasound (CEUS), to identify the SLNs in three superficial anatomical regions in an animal model. Six healthy laboratory dogs were included in a proof‐of‐concept trial. A NIR fluorescent d …
DOI: 10.1111/vco.12449
Article Source: USDA Pub Ag
